![]() ![]() Regarding other treatments, only one study for each method fitted the inclusion criteria, so the evidence was very limited.Ĭonclusion: Topical CAIs, oral CAIs and local steroids are effective in treating RP-CME. The effects of anti-VEGF reagents varied among studies. CAIs and local steroids were proved to be effective in reducing CMT. Treatments for RP-CME included oral and topical carbonic anhydrase inhibitors (CAIs), systematic and local steroids, anti-VEGF therapy, NSAIDS, grid LASER photocoagulation, subliminal micropulse LASER, vitrectomy, lutein supplement and oral minocycline. Results: Thirty-two studies were included in the current systematic review and 7 studies were used for meta-analysis. ![]() The secondary outcomes included fluorescein angiography (FA) leakage, rebound of CME and adverse effects. ![]() The primary outcomes included the change of central macular thickness (CMT) and best-corrected visual acuity (BCVA) from baseline. Review manager (Revman) was used to pool the data. The RoB 2 tool was used to evaluate the risk of bias of randomized controlled trials (RCTs), and the MINORS scale was used to assess the methodological quality of non-RCTs. Only studies published in English were included. , WHO ICTRP and ISRCTN were also searched for relevant studies. Methods: PubMed, Embase and the Cochrane library were searched from inception to August 2021. We performed a systematic review and meta-analysis to evaluate the efficacy and safety of current treatments for RP-CME. 5Key Laboratory of Yunnan Province for the Prevention and Treatment of Ophthalmic Diseases, Yunnan Eye Institute, Kunming, Chinaīackground: To date, various treatments for cystoid macular edema (CME) in retinitis pigmentosa (RP) have been reported.4Yunnan Clinical Medicine Center for Ocular Disease, Yunnan Eye Institute, Kunming, China.3Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.2Beijing Ophthalmology and Visual Science Key Laboratory, Beijing Institute of Ophthalmology, Beijing, China.1Department of Ophthalmology, The Second People's Hospital of Yunnan Province (Affiliated Hospital of Yunnan University, Fourth Affiliated Hospital of Kunming Medical University), Kunming, China.Chen Chen 1,4,5, Xia Liu 1,4,5 and Xiaoyan Peng 2,3 * ![]()
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